Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and its SM subunit Vps33, is followed by subsequent zip...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Schwartz, Matthew L, Nickerson, Daniel P, Lobingier, Braden T, Plemel, Rachael L, Duan, Mengtong, Angers, Cortney G, Zick, Michael, Merz, Alexey J
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
Предметы:
Biochemistry and Chemical Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643095/
https://ncbi.nlm.nih.gov/pubmed/28925353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27396
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