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Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

Membrane fusion requires R-, Qa-, Qb-, and Qc-family SNAREs that zipper into RQaQbQc coiled coils, driven by the sequestration of apolar amino acids. Zippering has been thought to provide all the force driving fusion. Sec17/αSNAP can form an oligomeric assembly with SNAREs with the Sec17 C-terminus...

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Detalhes bibliográficos
Publicado no:eLife
Principais autores: Song, Hongki, Torng, Thomas L, Orr, Amy S, Brunger, Axel T, Wickner, William T
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143792/
https://ncbi.nlm.nih.gov/pubmed/33944780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67578
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