Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and its SM subunit Vps33, is followed by subsequent zip...

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Publicado en:eLife
Autores principales: Schwartz, Matthew L, Nickerson, Daniel P, Lobingier, Braden T, Plemel, Rachael L, Duan, Mengtong, Angers, Cortney G, Zick, Michael, Merz, Alexey J
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643095/
https://ncbi.nlm.nih.gov/pubmed/28925353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27396
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