Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and its SM subunit Vps33, is followed by subsequent zip...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Schwartz, Matthew L, Nickerson, Daniel P, Lobingier, Braden T, Plemel, Rachael L, Duan, Mengtong, Angers, Cortney G, Zick, Michael, Merz, Alexey J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643095/
https://ncbi.nlm.nih.gov/pubmed/28925353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27396
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items