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SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

Secretory and endolysosomal fusion events are driven by SNAREs and cofactors, including Sec17/α-SNAP, Sec18/NSF, and Sec1/Munc18 (SM) proteins. SMs are essential for fusion in vivo, but the basis of this requirement is enigmatic. We now report that, in addition to their established roles as fusion a...

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Détails bibliographiques
Auteurs principaux: Lobingier, Braden T, Nickerson, Daniel P, Lo, Sheng-Ying, Merz, Alexey J
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060006/
https://ncbi.nlm.nih.gov/pubmed/24837546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02272
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