First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis

OBJECTIVE: Adequate platelet reactivity is required for maintain hemostasis. However, excessive platelet reactivity can also lead to the formation of occlusive thrombi. 12-lipoxygenase (12-LOX), an oxygenase highly expressed in the platelet, has been demonstrated to regulate platelet function and th...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Adili, Reheman, Tourdot, Benjamin E., Mast, Katherine, Yeung, Jennifer, Freedman, John Cody, Green, Abigail, Luci, Diane K., Jadhav, Ajit, Simeonov, Anton, Maloney, David J., Holman, Theodore R, Holinstat, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620123/
https://ncbi.nlm.nih.gov/pubmed/28775075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309868
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