12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor

The dihomo-γ-linolenic acid (DGLA)–derived metabolite of 12-lipoxygenase, 12-hydroxy-eicosatrienoic acid (12-HETrE), was recently shown to potently inhibit thrombus formation without prolonging bleeding in murine models. Although 12-HETrE was found to inhibit platelet activation via the Gα(s) signal...

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Udgivet i:Blood Adv
Main Authors: Tourdot, Benjamin E., Adili, Reheman, Isingizwe, Zitha R., Ebrahem, Meral, Freedman, J. Cody, Holman, Theodore R., Holinstat, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728320/
https://ncbi.nlm.nih.gov/pubmed/29296755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006155
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