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12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor
The dihomo-γ-linolenic acid (DGLA)–derived metabolite of 12-lipoxygenase, 12-hydroxy-eicosatrienoic acid (12-HETrE), was recently shown to potently inhibit thrombus formation without prolonging bleeding in murine models. Although 12-HETrE was found to inhibit platelet activation via the Gα(s) signal...
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| Publicado en: | Blood Adv |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728320/ https://ncbi.nlm.nih.gov/pubmed/29296755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006155 |
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