Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner

Arterial thrombosis is the underlying cause for a number of cardiovascular-related events. Although dietary supplementation that includes polyunsaturated fatty acids (PUFAs) has been proposed to elicit cardiovascular protection, a mechanism for antithrombotic protection has not been well established...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Yeung, Jennifer, Adili, Reheman, Yamaguchi, Adriana, Freedman, Cody J., Chen, Angela, Shami, Ryan, Das, Aditi, Holman, Theodore R., Holinstat, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509882/
https://ncbi.nlm.nih.gov/pubmed/32946570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002493
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