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First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis
OBJECTIVE: Adequate platelet reactivity is required for maintain hemostasis. However, excessive platelet reactivity can also lead to the formation of occlusive thrombi. 12-lipoxygenase (12-LOX), an oxygenase highly expressed in the platelet, has been demonstrated to regulate platelet function and th...
Zapisane w:
| Wydane w: | Arterioscler Thromb Vasc Biol |
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| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5620123/ https://ncbi.nlm.nih.gov/pubmed/28775075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309868 |
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