Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet activity often results in thrombotic complications leading to myocardial infarction and stroke. Activation of the FcγRIIa receptor leads to immune-mediated thrombosis, which i...

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Bibliographic Details
Main Authors: Yeung, Jennifer, Tourdot, Benjamin E., Fernandez-Perez, Pilar, Vesci, Joanne, Ren, Jin, Smyrniotis, Christopher J., Luci, Diane K., Jadhav, Ajit, Simeonov, Anton, Maloney, David J., Holman, Theodore R., McKenzie, Steven E., Holinstat, Michael
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183986/
https://ncbi.nlm.nih.gov/pubmed/25100742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575878
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