DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway

BACKGROUND: The effects of the docosahexaenoic acid (DHA) on cardiovascular disease are controversial and a mechanistic understanding of how this ω-3 polyunsaturated fatty (ω-3 PUFA) regulates platelet reactivity and the subsequent risk of a thrombotic event is warranted. In platelets, DHA is oxidiz...

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Vydáno v:J Thromb Haemost
Hlavní autoři: Yamaguchi, Adriana, Stanger, Livia, Freedman, Cody J, Standley, Melissa, Hoang, Timothy, Reheman, Adili, Wan-Chen, Tsai, van Hoorebeke, Christopher, Holman, Theodore R., Holinstat, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925359/
https://ncbi.nlm.nih.gov/pubmed/33222370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15184
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