Tau exacerbates excitotoxic brain damage in an animal model of stroke

Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau(−/−)) mice are profoundly protected from excitotoxic brain damage and neurological deficits following experimental stroke, using a middle cere...

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Udgivet i:Nat Commun
Main Authors: Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Ittner, Arne, Przybyla, Magdalena, van Hummel, Annika, Chua, Sook Wern, van der Hoven, Julia, Lee, Wei S., Müller, Julius, Parmar, Jasneet, Jonquieres, Georg von, Stefen, Holly, Guccione, Ernesto, Fath, Thomas, Housley, Gary D., Klugmann, Matthias, Ke, Yazi D., Ittner, Lars M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589746/
https://ncbi.nlm.nih.gov/pubmed/28883427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00618-0
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