Tau exacerbates excitotoxic brain damage in an animal model of stroke

Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau(−/−)) mice are profoundly protected from excitotoxic brain damage and neurological deficits following experimental stroke, using a middle cere...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Ittner, Arne, Przybyla, Magdalena, van Hummel, Annika, Chua, Sook Wern, van der Hoven, Julia, Lee, Wei S., Müller, Julius, Parmar, Jasneet, Jonquieres, Georg von, Stefen, Holly, Guccione, Ernesto, Fath, Thomas, Housley, Gary D., Klugmann, Matthias, Ke, Yazi D., Ittner, Lars M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589746/
https://ncbi.nlm.nih.gov/pubmed/28883427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00618-0
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