Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding protein 43 (TDP-43) caused by unknown mechanisms. Here, we studied TDP-43 in primary neurons under different stress conditions and found that...

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Detalhes bibliográficos
Main Authors: van Eersel, Janet, Ke, Yazi D., Gladbach, Amadeus, Bi, Mian, Götz, Jürgen, Kril, Jillian J., Ittner, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146516/
https://ncbi.nlm.nih.gov/pubmed/21829535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022850
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