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Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both. There is increasing evidence that insulin also plays a role in Alzheimer's disease (AD) as it is involved in the metabolism of β-amyloid (Aβ) and tau, two proteins that form Aβ pla...

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Detalhes bibliográficos
Main Authors: Ke, Yazi D., Delerue, Fabien, Gladbach, Amadeus, Götz, Jürgen, Ittner, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775636/
https://ncbi.nlm.nih.gov/pubmed/19936237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007917
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