Accelerated aging exacerbates a pre‐existing pathology in a tau transgenic mouse model

Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To observe how an aging phenotype interacts with and affects the pathological intracellular accumulation of hyperphosphorylated tau, the tauopathy mouse model pR5 (expressing P301L mutant human tau) was ba...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Bodea, Liviu‐Gabriel, Evans, Harrison Tudor, Van der Jeugd, Ann, Ittner, Lars M., Delerue, Fabien, Kril, Jillian, Halliday, Glenda, Hodges, John, Kiernan, Mathew C., Götz, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334525/
https://ncbi.nlm.nih.gov/pubmed/28160413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12565
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