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Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

One of the main pathological hallmarks of Alzheimer’s disease (AD) is the intraneuronal accumulation of hyperphosphorylated tau. Passive immunotherapy is a promising strategy for the treatment of AD and there are currently a number of tau-specific monoclonal antibodies in clinical trials. A proposed...

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Publicado en:Acta Neuropathol Commun
Autores principales: Bajracharya, Rinie, Brici, David, Bodea, Liviu-Gabriel, Janowicz, Phillip W., Götz, Jürgen, Nisbet, Rebecca M.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953551/
https://ncbi.nlm.nih.gov/pubmed/33712083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01147-0
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