Tau physiology and pathomechanisms in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular aggregates of hyperphosphorylated tau (FTLD‐tau). Moreover, genetic studies identified mutations in the MAPT gene encoding tau in familial cases of the disease. In this review, we cover a range of aspects of tau fu...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Bodea, Liviu‐Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier, Götz, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Frontotemporal dementias: From molecular mechanisms to therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094566/
https://ncbi.nlm.nih.gov/pubmed/27306859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13600
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