CNS cell type–specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation

The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal degeneration. Tau aggregates can form in different cell types...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ke, Yazi D., Chan, Gabriella, Stefanoska, Kristie, Au, Carol, Bi, Mian, Müller, Julius, Przybyla, Magdalena, Feiten, Astrid, Prikas, Emmanuel, Halliday, Glenda M., Piguet, Olivier, Kiernan, Matthew C., Kassiou, Michael, Hodges, John R., Loy, Clement T., Mattick, John S., Ittner, Arne, Kril, Jillian J., Sutherland, Greg T., Ittner, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755788/
https://ncbi.nlm.nih.gov/pubmed/31366728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005263
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