Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure

Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of cellu...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Dagnell, Markus, Pace, Paul E., Cheng, Qing, Frijhoff, Jeroen, Östman, Arne, Arnér, Elias S. J., Hampton, Mark B., Winterbourn, Christine C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582832/
https://ncbi.nlm.nih.gov/pubmed/28684416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.793745
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