Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

The inhibitory reversible oxidation of protein tyrosine phosphatases (PTPs) is an important regulatory mechanism in growth factor signaling. Studies on PTP oxidation have focused on pathways that increase or decrease reactive oxygen species levels and thereby affect PTP oxidation. The processes invo...

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Bibliographische Detailangaben
Hauptverfasser: Dagnell, Markus, Frijhoff, Jeroen, Pader, Irina, Augsten, Martin, Boivin, Benoit, Xu, Jianqiang, Mandal, Pankaj K., Tonks, Nicholas K., Hellberg, Carina, Conrad, Marcus, Arnér, Elias S. J., Östman, Arne
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746926/
https://ncbi.nlm.nih.gov/pubmed/23901112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302891110
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