12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive oxygen species (ROS), like H(2)O(2), as the mediators of PTP oxidation. The potential role(s) of peroxidized lipids in PTP oxidation have not be...

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Autors principals: Conrad, Marcus, Sandin, Åsa, Förster, Heidi, Seiler, Alexander, Frijhoff, Jeroen, Dagnell, Markus, Bornkamm, Georg W., Rådmark, Olof, van Huijsduijnen, Rob Hooft, Aspenström, Pontus, Böhmer, Frank, Östman, Arne
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936618/
https://ncbi.nlm.nih.gov/pubmed/20798033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007909107
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