12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive oxygen species (ROS), like H(2)O(2), as the mediators of PTP oxidation. The potential role(s) of peroxidized lipids in PTP oxidation have not be...

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Detalhes bibliográficos
Main Authors: Conrad, Marcus, Sandin, Åsa, Förster, Heidi, Seiler, Alexander, Frijhoff, Jeroen, Dagnell, Markus, Bornkamm, Georg W., Rådmark, Olof, van Huijsduijnen, Rob Hooft, Aspenström, Pontus, Böhmer, Frank, Östman, Arne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936618/
https://ncbi.nlm.nih.gov/pubmed/20798033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007909107
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