Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure

Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of cellu...

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Publicado en:J Biol Chem
Autores principales: Dagnell, Markus, Pace, Paul E., Cheng, Qing, Frijhoff, Jeroen, Östman, Arne, Arnér, Elias S. J., Hampton, Mark B., Winterbourn, Christine C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582832/
https://ncbi.nlm.nih.gov/pubmed/28684416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.793745
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