Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure

Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of cellu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Dagnell, Markus, Pace, Paul E., Cheng, Qing, Frijhoff, Jeroen, Östman, Arne, Arnér, Elias S. J., Hampton, Mark B., Winterbourn, Christine C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582832/
https://ncbi.nlm.nih.gov/pubmed/28684416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.793745
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