Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

Protein-tyrosine phosphatases (PTPs) counteract protein tyrosine phosphorylation and cooperate with receptor-tyrosine kinases in the regulation of cell signaling. PTPs need to undergo oxidative inhibition for activation of cellular cascades of protein-tyrosine kinase phosphorylation following growth...

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Pubblicato in:J Biol Chem
Autori principali: Dagnell, Markus, Cheng, Qing, Rizvi, Syed Husain Mustafa, Pace, Paul E., Boivin, Benoit, Winterbourn, Christine C., Arnér, Elias S. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699834/
https://ncbi.nlm.nih.gov/pubmed/31197039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009001
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