Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure

Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of cellu...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Dagnell, Markus, Pace, Paul E., Cheng, Qing, Frijhoff, Jeroen, Östman, Arne, Arnér, Elias S. J., Hampton, Mark B., Winterbourn, Christine C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582832/
https://ncbi.nlm.nih.gov/pubmed/28684416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.793745
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