The contribution of homology arms to nuclease-assisted genome engineering

Designer nucleases like CRISPR/Cas9 enable fluent site-directed damage or small mutations in many genomes. Strategies for their use to achieve more complex tasks like regional exchanges for gene humanization or the establishment of conditional alleles are still emerging. To optimize Cas9-assisted ta...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Baker, Oliver, Tsurkan, Sarah, Fu, Jun, Klink, Barbara, Rump, Andreas, Obst, Mandy, Kranz, Andrea, Schröck, Evelin, Anastassiadis, Konstantinos, Stewart, A. Francis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Synthetic Biology and Bioengineering
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570031/
https://ncbi.nlm.nih.gov/pubmed/28582546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx497
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