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Nuclease-mediated gene editing by homologous recombination of the human globin locus
Tal-effector nucleases (TALENs) are engineered proteins that can stimulate precise genome editing through specific DNA double-strand breaks. Sickle cell disease and β-thalassemia are common genetic disorders caused by mutations in β-globin, and we engineered a pair of highly active TALENs that induc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902937/ https://ncbi.nlm.nih.gov/pubmed/24157834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt947 |
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