Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification

Recent studies have shown that zinc finger nucleases (ZFNs) are powerful reagents for making site-specific genomic modifications. The generic structure of these enzymes includes a ZF DNA-binding domain and nuclease domain (Fn) are separated by an amino acid “linker” and cut genomic DNA at sites that...

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Main Authors: Wilson, Kimberly A, McEwen, Abbye E, Pruett-Miller, Shondra M, Zhang, Jiuli, Kildebeck, Eric J, Porteus, Matthew H
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650245/
https://ncbi.nlm.nih.gov/pubmed/23632390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.13
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