Gene Correction by Homologous Recombination With Zinc Finger Nucleases in Primary Cells From a Mouse Model of a Generic Recessive Genetic Disease

Zinc Finger nucleases (ZFNs) have been used to create precise genome modifications at frequencies that might be therapeutically useful in gene therapy. We created a mouse model of a generic recessive genetic disease to establish a preclinical system to develop the use of ZFN-mediated gene correction...

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Bibliografische gegevens
Hoofdauteurs: Connelly, Jon P, Barker, Jenny C, Pruett-Miller, Shondra, Porteus, Matthew H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2010
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889743/
https://ncbi.nlm.nih.gov/pubmed/20389291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.57
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