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Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
Zinc finger nucleases (ZFNs) have been used successfully to create genome-specific double-strand breaks and thereby stimulate gene targeting by several thousand fold. ZFNs are chimeric proteins composed of a specific DNA-binding domain linked to a non-specific DNA-cleavage domain. By changing key re...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633050/ https://ncbi.nlm.nih.gov/pubmed/19214211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000376 |
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