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Engineered Zinc Finger Nuclease–Mediated Homologous Recombination of the Human Rhodopsin Gene
PURPOSE. Novel zinc finger nucleases (ZFNs) were designed to target the human rhodopsin gene and induce homologous recombination of a donor DNA fragment. METHODS. Three-finger zinc finger nucleases were designed based on previously published guidelines. To assay for ZFN specificity, the authors gene...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Association for Research in Vision and Ophthalmology, Inc.
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055761/ https://ncbi.nlm.nih.gov/pubmed/20671268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5781 |
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