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Targeted gene inactivation in zebrafish using engineered zinc finger nucleases
In most vertebrate model systems direct genomic manipulation at a specific locus is still not feasible. Zinc finger nucleases (ZFNs) provide a system to introduce genomic lesions at a specific site in vertebrate cell lines1-3. Here, we adapt this technology to create targeted mutations in the zebraf...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2502069/ https://ncbi.nlm.nih.gov/pubmed/18500337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1398 |
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