Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate a straightforward modular assembly-based approach for ZFN construction and gene inactivation in zebrafish. Fro...

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書誌詳細
主要な著者: Zhu, Cong, Smith, Tom, McNulty, Joseph, Rayla, Amy L., Lakshmanan, Abirami, Siekmann, Arndt F., Buffardi, Matthew, Meng, Xiangdong, Shin, Jimann, Padmanabhan, Arun, Cifuentes, Daniel, Giraldez, Antonio J., Look, A. Thomas, Epstein, Jonathan A., Lawson, Nathan D., Wolfe, Scot A.
フォーマット: Artigo
言語:Inglês
出版事項: Company of Biologists 2011
主題:
Technical Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177320/
https://ncbi.nlm.nih.gov/pubmed/21937602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.066779
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