Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate a straightforward modular assembly-based approach for ZFN construction and gene inactivation in zebrafish. Fro...

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Autori principali: Zhu, Cong, Smith, Tom, McNulty, Joseph, Rayla, Amy L., Lakshmanan, Abirami, Siekmann, Arndt F., Buffardi, Matthew, Meng, Xiangdong, Shin, Jimann, Padmanabhan, Arun, Cifuentes, Daniel, Giraldez, Antonio J., Look, A. Thomas, Epstein, Jonathan A., Lawson, Nathan D., Wolfe, Scot A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2011
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Technical Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177320/
https://ncbi.nlm.nih.gov/pubmed/21937602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.066779
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