Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate a straightforward modular assembly-based approach for ZFN construction and gene inactivation in zebrafish. Fro...

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Main Authors: Zhu, Cong, Smith, Tom, McNulty, Joseph, Rayla, Amy L., Lakshmanan, Abirami, Siekmann, Arndt F., Buffardi, Matthew, Meng, Xiangdong, Shin, Jimann, Padmanabhan, Arun, Cifuentes, Daniel, Giraldez, Antonio J., Look, A. Thomas, Epstein, Jonathan A., Lawson, Nathan D., Wolfe, Scot A.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2011
Teme:
Technical Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177320/
https://ncbi.nlm.nih.gov/pubmed/21937602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.066779
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