Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish

Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms. However, construction of target-specific ZFNs is technically challenging. Here, we evaluate a straightforward modular assembly-based approach for ZFN construction and gene inactivation in zebrafish. Fro...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhu, Cong, Smith, Tom, McNulty, Joseph, Rayla, Amy L., Lakshmanan, Abirami, Siekmann, Arndt F., Buffardi, Matthew, Meng, Xiangdong, Shin, Jimann, Padmanabhan, Arun, Cifuentes, Daniel, Giraldez, Antonio J., Look, A. Thomas, Epstein, Jonathan A., Lawson, Nathan D., Wolfe, Scot A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Company of Biologists 2011
Konular:
Technical Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177320/
https://ncbi.nlm.nih.gov/pubmed/21937602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.066779
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