Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

Zinc finger nucleases (ZFNs) facilitate tailor-made genomic modifications in vivo through the creation of targeted double-stranded breaks. They have been employed to modify the genomes of plants and animals, and cell-based therapies utilizing ZFNs are undergoing clinical trials. However, many ZFNs d...

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Bibliografiske detaljer
Main Authors: Gupta, Ankit, Meng, Xiangdong, Zhu, Lihua J., Lawson, Nathan D., Wolfe, Scot A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Synthetic Biology and Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017618/
https://ncbi.nlm.nih.gov/pubmed/20843781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq787
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