Using defined finger–finger interfaces as units of assembly for constructing zinc-finger nucleases

Zinc-finger nucleases (ZFNs) have been used for genome engineering in a wide variety of organisms; however, it remains challenging to design effective ZFNs for many genomic sequences using publicly available zinc-finger modules. This limitation is in part because of potential finger–finger incompati...

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Detalhes bibliográficos
Main Authors: Zhu, Cong, Gupta, Ankit, Hall, Victoria L., Rayla, Amy L., Christensen, Ryan G., Dake, Benjamin, Lakshmanan, Abirami, Kuperwasser, Charlotte, Stormo, Gary D., Wolfe, Scot A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575815/
https://ncbi.nlm.nih.gov/pubmed/23303772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1357
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