Targeted Gene Addition in Human Epithelial Stem Cells by Zinc-finger Nuclease-mediated Homologous Recombination

Preclinical and clinical studies showed that autologous transplantation of epidermis derived from genetically modified epithelial stem cells (EpSCs) leads to long-term correction of inherited skin adhesion defects. These studies were based on potentially genotoxic retroviral vectors. We developed an...

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Hlavní autoři: Coluccio, Andrea, Miselli, Francesca, Lombardo, Angelo, Marconi, Alessandra, Malagoli Tagliazucchi, Guidantonio, Gonçalves, Manuel A, Pincelli, Carlo, Maruggi, Giulietta, Del Rio, Marcela, Naldini, Luigi, Larcher, Fernando, Mavilio, Fulvio, Recchia, Alessandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776632/
https://ncbi.nlm.nih.gov/pubmed/23760447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.143
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