The contribution of homology arms to nuclease-assisted genome engineering

Designer nucleases like CRISPR/Cas9 enable fluent site-directed damage or small mutations in many genomes. Strategies for their use to achieve more complex tasks like regional exchanges for gene humanization or the establishment of conditional alleles are still emerging. To optimize Cas9-assisted ta...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Baker, Oliver, Tsurkan, Sarah, Fu, Jun, Klink, Barbara, Rump, Andreas, Obst, Mandy, Kranz, Andrea, Schröck, Evelin, Anastassiadis, Konstantinos, Stewart, A. Francis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Synthetic Biology and Bioengineering
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570031/
https://ncbi.nlm.nih.gov/pubmed/28582546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx497
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