The contribution of homology arms to nuclease-assisted genome engineering

Designer nucleases like CRISPR/Cas9 enable fluent site-directed damage or small mutations in many genomes. Strategies for their use to achieve more complex tasks like regional exchanges for gene humanization or the establishment of conditional alleles are still emerging. To optimize Cas9-assisted ta...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Baker, Oliver, Tsurkan, Sarah, Fu, Jun, Klink, Barbara, Rump, Andreas, Obst, Mandy, Kranz, Andrea, Schröck, Evelin, Anastassiadis, Konstantinos, Stewart, A. Francis
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Synthetic Biology and Bioengineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570031/
https://ncbi.nlm.nih.gov/pubmed/28582546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx497
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