Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites

A series of analogues based on serine as lead structure were designed, and their agonist activities were evaluated at recombinant NMDA receptor subtypes (GluN1/2A–D) using two-electrode voltage-clamp (TEVC) electrophysiology. Pronounced variation in subunit-selectivity, potency, and agonist efficacy...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Maolanon, Alex R., Risgaard, Rune, Wang, Shuang-Yan, Snoep, Yoran, Papangelis, Athanasios, Yi, Feng, Holley, David, Barslund, Anne F., Svenstrup, Niels, Hansen, Kasper B., Clausen, Rasmus P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559341/
https://ncbi.nlm.nih.gov/pubmed/28514141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00117
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