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Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists

We developed a versatile stereoselective route for the synthesis of new 2′-(S)-CCG-IV analogues. The route allows for late stage diversification and thereby provides access to a great variety of conformationally restricted cyclopropyl glutamate analogues. A selection of the 2′-(S)-CCG-IV analogues w...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Maolanon, Alex, Papangelis, Athanasios, Kawiecki, David, Mou, Tung-Chung, Syrenne, Jed T., Yi, Feng, Hansen, Kasper B., Clausen, Rasmus P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325387/
https://ncbi.nlm.nih.gov/pubmed/33383257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.113099
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