Development of 2′-substituted (2S,1′R,2′S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists

A series of 2′-substituted analogues of the selective NMDA receptor ligand (2S,1′R,2′S)-2-(carboxycyclopropyl)glycine ((S)-CCG-IV) have been designed, synthesized and pharmacologically characterized. The design was based on a docking study hypothesizing that substituents in the 2′-position would pro...

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Main Authors: Risgaard, Rune, Nielsen, Simon D., Hansen, Kasper B., Jensen, Christina M., Nielsen, Birgitte, Traynelis, Stephen F., Clausen, Rasmus P.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689883/
https://ncbi.nlm.nih.gov/pubmed/23614571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400346a
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