Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-d-Aspartate Receptors

N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2 subunits. We used a series of N-hydroxypyrazole-5-glycine (NHP5G) partial agonists at the GluN2 glutamate binding site as tools to study activation of GluN1/GluN2A and GluN1/GluN2D NMDA receptor subtyp...

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Detalhes bibliográficos
Main Authors: Hansen, Kasper B., Tajima, Nami, Risgaard, Rune, Perszyk, Riley E., Jørgensen, Lars, Vance, Katie M., Ogden, Kevin K., Clausen, Rasmus P., Furukawa, Hiro, Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684824/
https://ncbi.nlm.nih.gov/pubmed/23625947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.085803
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