N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine...

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Pubblicato in:J Med Chem
Autori principali: Clausen, Rasmus P., Christensen, Caspar, Hansen, Kasper B., Greenwood, Jeremy R., Jørgensen, Lars, Micale, Nicola, Madsen, Jens Christian, Nielsen, Birgitte, Egebjerg, Jan, Bräuner-Osborne, Hans, Traynelis, Stephen F., Kristensen, Jesper L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850074/
https://ncbi.nlm.nih.gov/pubmed/18578474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800025e
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