N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Clausen, Rasmus P., Christensen, Caspar, Hansen, Kasper B., Greenwood, Jeremy R., Jørgensen, Lars, Micale, Nicola, Madsen, Jens Christian, Nielsen, Birgitte, Egebjerg, Jan, Bräuner-Osborne, Hans, Traynelis, Stephen F., Kristensen, Jesper L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850074/
https://ncbi.nlm.nih.gov/pubmed/18578474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800025e
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker