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N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Clausen, Rasmus P., Christensen, Caspar, Hansen, Kasper B., Greenwood, Jeremy R., Jørgensen, Lars, Micale, Nicola, Madsen, Jens Christian, Nielsen, Birgitte, Egebjerg, Jan, Bräuner-Osborne, Hans, Traynelis, Stephen F., Kristensen, Jesper L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850074/
https://ncbi.nlm.nih.gov/pubmed/18578474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800025e
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