N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Clausen, Rasmus P., Christensen, Caspar, Hansen, Kasper B., Greenwood, Jeremy R., Jørgensen, Lars, Micale, Nicola, Madsen, Jens Christian, Nielsen, Birgitte, Egebjerg, Jan, Bräuner-Osborne, Hans, Traynelis, Stephen F., Kristensen, Jesper L.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850074/
https://ncbi.nlm.nih.gov/pubmed/18578474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800025e
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires