Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-d-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

NMDA receptors are ligand-gated ion channels that mediate excitatory neurotransmission in the brain. They are tetrameric complexes composed of glycine-binding GluN1 and GluN3 subunits together with glutamate-binding GluN2 subunits. Subunit-selective antagonists that discriminate between the glycine...

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Main Authors: Kvist, Trine, Steffensen, Thomas Bielefeldt, Greenwood, Jeremy R., Mehrzad Tabrizi, Fatemeh, Hansen, Kasper B., Gajhede, Michael, Pickering, Darryl S., Traynelis, Stephen F., Kastrup, Jette Sandholm, Bräuner-Osborne, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829161/
https://ncbi.nlm.nih.gov/pubmed/24072709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480210
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