Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake

Stem cell–derived platelets have the potential to replace donor platelets for transfusion. Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture may help to optimize the in vitro generation of platelets. Using 2 human stem cell models of megakaryopoiesis, we identi...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Sim, Xiuli, Jarocha, Danuta, Hayes, Vincent, Hanby, Hayley A., Marks, Michael S., Camire, Rodney M., French, Deborah L., Poncz, Mortimer, Gadue, Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Platelets and Thrombopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510789/
https://ncbi.nlm.nih.gov/pubmed/28455282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-01-761049
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