FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology

Friend leukemia virus integration 1 (FLI1), a critical transcription factor (TF) during megakaryocyte differentiation, is among genes hemizygously deleted in Jacobsen syndrome, resulting in a macrothrombocytopenia termed Paris-Trousseau syndrome (PTSx). Recently, heterozygote human FLI1 mutations ha...

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Bibliographic Details
Published in:Blood
Main Authors: Vo, Karen K., Jarocha, Danuta J., Lyde, Randolph B., Hayes, Vincent, Thom, Christopher S., Sullivan, Spencer K., French, Deborah L., Poncz, Mortimer
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492092/
https://ncbi.nlm.nih.gov/pubmed/28432223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-770958
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