Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A

B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIII(null) mice, even in the presence of circulating inhibitors. However, our prior studies have shown that this ectopically express...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Adv
Prif Awduron: Lyde, Randolph B., Ahn, Hyun Sook, Vo, Karen K., Jarocha, Danuta J., Tkaczynski, John, Treffeisen, Elsa, Sullivan, Spencer K., Camire, Rodney M., Sabatino, Denise E., French, Deborah L., Poncz, Mortimer
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2019
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517653/
https://ncbi.nlm.nih.gov/pubmed/31036722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007914
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg