In vivo efficacy of platelet-delivered, high specific activity factor VIII variants

Ectopically expressed, human B-domainless (hB) factor 8 (F8) in platelets improves hemostasis in hemophilia A mice in several injury models. However, in both a cuticular bleeding model and a cremaster laser arteriole/venule injury model, there were limitations to platelet-derived (p) hBF8 efficacy,...

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Detalhes bibliográficos
Main Authors: Greene, Teshell K., Wang, Cheng, Hirsch, Jessica D., Zhai, Li, Gewirtz, Jamie, Thornton, Michael A., Miao, Hongzhi Z., Pipe, Steven W., Kaufman, Randal J., Camire, Rodney M., Arruda, Valder R., Kowalska, M. Anna, Poncz, Mortimer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031396/
https://ncbi.nlm.nih.gov/pubmed/20852129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-293308
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