In vivo efficacy of platelet-delivered, high specific activity factor VIII variants

Ectopically expressed, human B-domainless (hB) factor 8 (F8) in platelets improves hemostasis in hemophilia A mice in several injury models. However, in both a cuticular bleeding model and a cremaster laser arteriole/venule injury model, there were limitations to platelet-derived (p) hBF8 efficacy,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Greene, Teshell K., Wang, Cheng, Hirsch, Jessica D., Zhai, Li, Gewirtz, Jamie, Thornton, Michael A., Miao, Hongzhi Z., Pipe, Steven W., Kaufman, Randal J., Camire, Rodney M., Arruda, Valder R., Kowalska, M. Anna, Poncz, Mortimer
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2010
Gaiak:
Thrombosis and Hemostasis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031396/
https://ncbi.nlm.nih.gov/pubmed/20852129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-293308
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