In vivo efficacy of platelet-delivered, high specific activity factor VIII variants

Ectopically expressed, human B-domainless (hB) factor 8 (F8) in platelets improves hemostasis in hemophilia A mice in several injury models. However, in both a cuticular bleeding model and a cremaster laser arteriole/venule injury model, there were limitations to platelet-derived (p) hBF8 efficacy,...

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Autores principales: Greene, Teshell K., Wang, Cheng, Hirsch, Jessica D., Zhai, Li, Gewirtz, Jamie, Thornton, Michael A., Miao, Hongzhi Z., Pipe, Steven W., Kaufman, Randal J., Camire, Rodney M., Arruda, Valder R., Kowalska, M. Anna, Poncz, Mortimer
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031396/
https://ncbi.nlm.nih.gov/pubmed/20852129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-293308
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